BNT162b2 Messenger RNA Vaccination Did Not Prevent an Outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 Variant 501Y.V2 in an Elderly Nursing Home but Reduced Transmission and Disease Severity
B. Bailly, Luc Guilpain, Kévin Bouiller, Catherine Chirouze, Mélissa N’Debi, Alexandre Soulier, Vanessa Démontant, Jean–Michel Pawlotsky, Christophe Rodriguez, Slim Fourati
Abstract
We report an outbreak of severe acute respiratory syndrome coronavirus 2 501Y.V2 in a nursing home. All nonvaccinated residents (5/5) versus half of those vaccinated with BNT162b2 (13/26) were infected. Two of 13 vaccinated versus 4 of 5 nonvaccinated residents presented severe disease. BNT162b2 did not prevent the outbreak, but reduced transmission and disease severity.
Topics & Concepts
MedicineOutbreakTransmission (telecommunications)VaccinationCoronavirus disease 2019 (COVID-19)Nursing homesDiseaseSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus2019-20 coronavirus outbreakIntensive care medicineImmunologyInternal medicineVirologyInfectious disease (medical specialty)NursingElectrical engineeringEngineeringSARS-CoV-2 and COVID-19 ResearchVaccine Coverage and HesitancyAnimal Virus Infections Studies