Enriching Proteolysis Targeting Chimeras with a Second Modality: When Two Are Better Than One
Alessandra Salerno, Francesca Seghetti, Jessica Caciolla, Elisa Uliassi, Eleonora Testi, Melissa Guardigni, Marinella Roberti, Andrea Milelli, María Laura Bolognesi
Abstract
PROTACs. A deeper and detailed understanding of the most critical challenges is required to fully exploit these opportunities and decisively enrich the PROTAC toolbox.
Topics & Concepts
ProteolysisChemistryModalitiesTherapeutic modalitiesDrug discoveryChimera (genetics)Computational biologyTreatment modalityModality (human–computer interaction)BiochemistryArtificial intelligenceComputer scienceEnzymeInternal medicineBiologyMedicineSocial scienceSociologyGeneProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysMultiple Myeloma Research and Treatments