Glycoengineering artificial receptors for microglia to phagocytose Aβ aggregates
Dongqin Yu, Chun Liu, Haochen Zhang, Jinsong Ren, Xiaogang Qu
Abstract
A combination of metabolic glycoengineering and self-triggered click chemistry is utilized to engineer a microglial membrane with ThS as artificial Aβ receptors to promote microglia to phagocytose Aβ aggregates.
Topics & Concepts
MicrogliaPhagocytosisReceptorChemistryNeuroscienceBiologyCell biologyImmunologyBiochemistryInflammationNeuroinflammation and Neurodegeneration MechanismsAdenosine and Purinergic SignalingGlycosylation and Glycoproteins Research