<i>tert</i>-Butyl nitrite triggered radical cascade reaction for synthesizing isoxazoles by a one-pot multicomponent strategy
Leijing Chen, Zhen Wang, Hui Liu, Xinyue Li, Bin Wang
Abstract
A metal-free radical cyclization/dehydrogenation cascade of alkenes with aldehydes has been developed for the synthesis of 3,5-disubstituted isoxazoles in a one-pot system. This protocol features excellent functional group tolerance and operational simplicity, and is easily scaled up. The radical process is well supported by TEMPO-adducts and the intermediate β-carbonyl ketoxime.
Topics & Concepts
ChemistryCascadeDehydrogenationAdductRadical cyclizationNitriteCombinatorial chemistryFunctional groupCascade reactionOrganic chemistryCatalysisNitratePolymerChromatographyCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSulfur-Based Synthesis Techniques