Discovery of new benzothiazole-1,2,3-triazole hybrid-based hydrazone/thiosemicarbazone derivatives as potent EGFR inhibitors with cytotoxicity against cancer
Ateyatallah Aljuhani, Mohamed S. Nafie, Nader R. Albujuq, Mosa Alsehli, Sanaa K. Bardaweel, Khaled M. Darwish, Shaya Y. Al‐Raqa, Mohamed Reda Aouad, Nadjet Rezki
Abstract
= 1.3 μM, 98.2% inhibition). Molecular docking results exhibited a good binding affinity of compounds 8a and 8b towards the EGFR active site. Accordingly, these compounds can be further developed as target-oriented EGFR chemotherapeutics against cancer.
Topics & Concepts
BenzothiazoleHydrazoneCytotoxicitySemicarbazoneChemistryTriazoleCombinatorial chemistryStereochemistryBiochemistryOrganic chemistryIn vitroClick Chemistry and ApplicationsSynthesis and biological activitySynthesis and Biological Evaluation