Surface-Charge-Switchable Nanoclusters for Magnetic Resonance Imaging-Guided and Glutathione Depletion-Enhanced Photodynamic Therapy
Jianzhi Zhu, Tingting Xiao, Jiulong Zhang, Hailong Che, Yuxin Shi, Xiangyang Shi, Jan C. M. van Hest
Abstract
experiments demonstrate that the CMGCC exhibit significantly enhanced PDT efficacy toward HeLa cells and subcutaneous HeLa tumors. Our study thereby demonstrates this to be a promising synergistic theranostic nanoplatform with highly efficient PDT performance for cancer therapy.
Topics & Concepts
Photodynamic therapySinglet oxygenGlutathioneHeLaIn vivoBiophysicsReactive oxygen speciesMaterials scienceHydrogen peroxideNanocagesChemistryTumor hypoxiaCatalaseIn vitroOxygenOxidative stressBiochemistryRadiation therapyEnzymeMedicineOrganic chemistryBiologyBiotechnologyInternal medicineCatalysisNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesAdvanced Nanomaterials in Catalysis