Intervertebral disc organ-on-a-chip: an innovative model to study monocyte extravasation during nucleus pulposus degeneration
Hyeong-Guk Son, Min Ho Hwang, S. Lee, An‐Gi Kim, Taewon Kim, Joo Han Kim, Hyuk Choi, Sehoon Jeong
Abstract
model of monocyte chemotaxis with degenerative NP on an IVD organ chip depicts the sequential processes of monocyte migration/infiltration, monocyte-to-macrophage differentiation, and accumulation. Using this platform to gain a deeper understanding of monocyte infiltration and differentiation processes can provide insights into the pathophysiology of the immune response in degenerative IVD.
Topics & Concepts
MonocyteCell biologyInfiltration (HVAC)Immune systemIntervertebral discChemotaxisCCL2InflammationCellular differentiationExtravasationChemistryImmunologyBiologyChemokineAnatomyMaterials scienceBiochemistryReceptorGeneComposite materialSpine and Intervertebral Disc PathologyMusculoskeletal pain and rehabilitationOsteoarthritis Treatment and Mechanisms