Obesity and Thyroid Cancer Risk: An Update
Fabiana Franchini, Giuseppe Palatucci, Annamaria Colao, Paola Ungaro, Paolo Emidio Macchia, Immacolata Cristina Nettore
2022International Journal of Environmental Research and Public Health105 citationsDOIOpen Access PDF
Abstract
Thyroid cancer (TC) is the most common endocrine malignancy worldwide and its incidence has increased dramatically in recent years. In parallel, the prevalence of overweight and obesity has also increased, suggesting a possible link between these two diseases. Indeed, low-grade chronic inflammation, altered cytokine levels, insulin resistance, oxidative stress, and hormonal changes that occur in obese patients are all factors that contribute to the occurrence and growth of TC. In this review, the most recent evidence supporting the potential role of the mechanisms linking obesity to TC will be discussed.
Topics & Concepts
ObesityThyroid cancerMedicineOverweightEndocrine systemInsulin resistanceIncidence (geometry)CancerMalignancyHormoneThyroidInflammationInternal medicinePhysiologyOncologyBioinformaticsEndocrinologyBiologyOpticsPhysicsThyroid Cancer Diagnosis and TreatmentGrowth Hormone and Insulin-like Growth FactorsAntioxidant Activity and Oxidative Stress