Visible-light-enabled aerobic oxidative C<sub>sp3</sub>–H functionalization of glycine derivatives using an organic photocatalyst: access to substituted quinoline-2-carboxylates
Jingxin Wang, Liqi Li, Ying Guo, Shengyu Li, Shutao Wang, Ying Li, Yuan Zhang
Abstract
A practical visible-light-induced aerobic oxidative dehydrogenative coupling reaction of glycine derivatives with olefins has been developed to efficiently synthesize quinoline-2-carboxylates. This metal-free process proceeds smoothly under mild conditions and exhibits good tolerance of functional groups. Given the low cost of the catalyst and feedstock materials, the mild reaction conditions and the absence of hazardous byproducts, this protocol should find broad applications in the synthesis of quinoline-2-carboxylate derivatives.
Topics & Concepts
ChemistrySurface modificationQuinolinePhotocatalysisGlycineOxidative phosphorylationVisible spectrumPhotochemistryCombinatorial chemistryMedicinal chemistryOrganic chemistryCatalysisAmino acidPhysical chemistryOptoelectronicsPhysicsBiochemistryRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsOxidative Organic Chemistry Reactions