Luteolin exhibits synergistic therapeutic efficacy with erastin to induce ferroptosis in colon cancer cells through the HIC1-mediated inhibition of GPX4 expression
Yinli Zheng, Leyan Li, Haipeng Chen, Yuting Zheng, Xuanjing Tan, Guiyu Zhang, Ruidi Jiang, Hong Yu, Senyi Lin, Yijie Wei, Ying Wang, Rong Zhang, Zhongqiu Liu, Jinjun Wu
Topics & Concepts
Colorectal cancerGPX4LuteolinCancer researchCancerCancer cellProgrammed cell deathDownregulation and upregulationIn vivoBiologyMedicineGlutathioneApoptosisGlutathione peroxidaseInternal medicineFlavonoidBiochemistryGeneEnzymeAntioxidantBiotechnologyFerroptosis and cancer prognosisCancer, Lipids, and MetabolismCancer-related molecular mechanisms research