Acute Kidney Injury Among Children Likely Associated with Diethylene Glycol–Contaminated Medications — The Gambia, June–September 2022
Parsa Bastani, Anna Jammeh, Frederica Lamar, Jason H. Malenfant, Peter Adewuyi, Alyson M. Cavanaugh, Kimberly N. Calloway, Carolyn Crisp, Nuha Fofana, T. Christy Hallett, Amadou T. Jallow, Uzoamaka Muoneke, Momodou Nyassi, Jerry R. Thomas, Alyssa N. Troeschel, Ellen Yard, Michael W. Yeh, Mustapha Bittaye
Abstract
On July 26, 2022, a pediatric nephrologist alerted The Gambia's Ministry of Health (MoH) to a cluster of cases of acute kidney injury (AKI) among young children at the country's sole teaching hospital, and on August 23, 2022, MoH requested assistance from CDC. CDC epidemiologists arrived in The Gambia, a West African country, on September 16 to assist MoH in characterizing the illness, describing the epidemiology, and identifying potential causal factors and their sources. Investigators reviewed medical records and interviewed caregivers to characterize patients' symptoms and identify exposures. The preliminary investigation suggested that various contaminated syrup-based children's medications contributed to the AKI outbreak. During the investigation, MoH recalled implicated medications from a single international manufacturer. Continued efforts to strengthen pharmaceutical quality control and event-based public health surveillance are needed to help prevent future medication-related outbreaks.