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Irisin protects against doxorubicin-induced cardiotoxicity by improving AMPK-Nrf2 dependent mitochondrial fusion and strengthening endogenous anti-oxidant defense mechanisms

Caili Zhuo, Juan-Juan Xin, Wenjing Huang, Die Zhang, Xin Yan, Ruli Li, He Li, Jie Lan, Lan Lin, Lingyu Li, Xuemei Wang, Linling Liu, Yingling Wang, Xinyue Li, Yan Mao, Hongying Chen, Sisi Wu, Xijing Yang, Wei Jiang

2023Toxicology37 citationsDOI

Topics & Concepts

AMPKOxidative stressCardiotoxicityFNDC5MitochondrionEndogenyEndocrinologyMitochondrial ROSInternal medicineCell biologyChemistryBiologyMedicineProtein kinase AToxicityKinaseExtracellular matrixFibronectinAdipose Tissue and MetabolismMitochondrial Function and PathologyGenomics, phytochemicals, and oxidative stress
Irisin protects against doxorubicin-induced cardiotoxicity by improving AMPK-Nrf2 dependent mitochondrial fusion and strengthening endogenous anti-oxidant defense mechanisms | Litcius