Human brain sialoglycan ligand for CD33, a microglial inhibitory Siglec implicated in Alzheimer’s disease
Anabel Gonzalez-Gil, Ryan N. Porell, Steve M. Fernandes, Eila Maenpaa, T August Li, Tong Li, Philip C. Wong, Kazuhiro Aoki, Michael Tiemeyer, Zaikuan Yu, Benjamin C. Orsburn, Namandjé N. Bumpus, Russell T. Matthews, Ronald L. Schnaar
Abstract
, may contribute to AD progression.
Topics & Concepts
SIGLECMicrogliaBiologyReceptorKeratan sulfateCell biologyChemistryBiochemistryImmunologyInflammationExtracellular matrixProteoglycanGlycosylation and Glycoproteins ResearchNeuroinflammation and Neurodegeneration MechanismsGalectins and Cancer Biology