Epitranscriptomic <i>N</i> <sup>6</sup> -Methyladenosine Profile of SARS-CoV-2-Infected Human Lung Epithelial Cells
Stacia Phillips, Tarun Mishra, Shaubhagya Khadka, Dana Bohan, Constanza E. Espada, Wendy Maury, Li Wu
Abstract
Posttranscriptional modification of viral and cellular RNA by N 6 -methyladenosine (m 6 A) plays an important role in regulating the replication of many viruses and the cellular immune response to infection. We therefore sought to define the epitranscriptomic m 6 A profile of human lung epithelial cells infected with SARS-CoV-2.
Topics & Concepts
N6-MethyladenosineBiologyRNAHuman lungImmune systemViral replicationCell biologyVirologyLungCell cultureGeneVirusImmunologyMethyltransferaseGeneticsMethylationMedicineInternal medicineRNA modifications and cancerCancer-related molecular mechanisms researchMicroRNA in disease regulation