Bilateral Acute Macular Neuroretinopathy After Vaccination Against SARS-CoV-2
Benedikt A. J. Book, Bárbara Schmidt, Andreas Foerster
Abstract
A 21-year-old woman in good health (best-corrected visual acuity, 20/16 OU) reported bilateral paracentral scotomas 3 days after receiving her first ).Ophthalmoscopy showed bilateral circumscribed paracentral dark lesions that were easily visible on infrared reflectance imaging (Figure ,A) and matched with outer plexiform layer thickening and discontinuity of the photoreceptor inner-segment ellipsoid band on optical coherence tomography (Figure ,B).Microperimetry demonstrated bilateral scotomas corresponding to these lesions.Bilateral acute macular neuroretinopathy was diagnosed.No additional ocu-lar, orbital, and cerebral pathologies were found on clinical ophthalmic, neurological, and imaging workups, including magnetic resonance angiography.Apart from birth control use (levonorgestrel and ethinylestradiol), the patient's medical history was unremarkable.Because acute macular neuroretinopathy was recently described in patients with COVID-19, 1 polymerase chain reaction testing for SARS-CoV-2 was performed, with a negative result.Given the idiopathic nature of acute macular neuroretinopathy and the hundreds of millions of people receiving COVID-19 vaccination, conclusions as to causality or direct correlation should not be drawn from this case.