Broad-Spectrum Antiviral Activity of 3′-Deoxy-3′-Fluoroadenosine against Emerging Flaviviruses
Luděk Eyer, Pavel Svoboda, Jan Balvan, Tomáš Vičar, Martina Raudenská, Michal Štefánik, Jan Haviernik, Ivana Huvarová, Petra Straková, Ivo Rudolf, Zdeněk Hubálek, Katherine L. Seley‐Radtke, Erik De Clercq, Daniel Růžek
Abstract
Emerging flaviviruses are causative agents of severe and life-threatening diseases, against which no approved therapies are available. Among the nucleoside analogues, which represent a promising group of potentially therapeutic compounds, fluorine-substituted nucleosides are characterized by unique structural and functional properties.
Topics & Concepts
VirologyBroad spectrumBiologyMedicineComputational biologyChemistryCombinatorial chemistryMosquito-borne diseases and controlHIV Research and TreatmentCytomegalovirus and herpesvirus research