Synthesis, biological evaluation, and <i>in silico</i> studies of novel chalcone- and pyrazoline-based 1,3,5-triazines as potential anticancer agents
Leydi M. Moreno, Jairo Quiroga, Rodrigo Abonı́a, Antonino Lauria, Annamaria Martorana, Henry Insuasty, Braulio Insuasty
Abstract
studies, for both ligand- and structure-based, were executed to explore the inhibitory nature of chalcones and triazine derivatives. The results suggested that the evaluated compounds could act as modulators of the human thymidylate synthase enzyme.
Topics & Concepts
ChemistryChalconeTriazineCyanuric chloridePyrazolineStereochemistryNucleophilic substitution1,3,5-TriazineCombinatorial chemistryMedicinal chemistryOrganic chemistrySynthesis and Characterization of Heterocyclic CompoundsSynthesis and biological activitySynthesis and Biological Evaluation