Deficiency of telomere-associated repressor activator protein 1 precipitates cardiac aging in mice <i>via</i> p53/PPARα signaling
Yin Cai, Hao Liu, Erfei Song, Lin Wang, Jindong Xu, Yi He, Dengwen Zhang, Liyan Zhang, Kenneth K.Y. Cheng, Leigang Jin, Min Wu, Shiming Liu, Dake Qi, Liangqing Zhang, Gary D. Lopaschuk, Sheng Wang, Aimin Xu, Zhengyuan Xia
Abstract
modulating the p53/PPARα signaling pathway, which could represent a therapeutic target in preventing/attenuating cardiac aging.
Topics & Concepts
RepressorTelomereActivator (genetics)Peroxisome proliferator-activated receptorCell biologyP53 proteinTranscription factorBiologySignal transductionInternal medicineEndocrinologyCancer researchReceptorChemistryMedicineGeneticsGeneTelomeres, Telomerase, and SenescenceAdipose Tissue and MetabolismGenetics, Aging, and Longevity in Model Organisms