Calmodulin acts as a state-dependent switch to control a cardiac potassium channel opening
Po Wei Kang, Annie M. Westerlund, Jingyi Shi, Kelli McFarland White, Alex Dou, Amy H. Cui, Jonathan R. Silva, Lucie Delemotte, Jianmin Cui
Abstract
and CaM in KCNQ1 voltage-dependent activation, yielding insights into how KCNQ1 gains the phenotypes critical for its physiological function.
Topics & Concepts
GatingCalmodulinPotassium channelBiophysicsChemistryCytosolElectrophysiologyOptogeneticsConformational changeCell biologyNeuroscienceBiologyBiochemistryEnzymeCardiac electrophysiology and arrhythmiasIon channel regulation and functionElectrochemical Analysis and Applications