AgNTf<sub>2</sub>-Catalyzed Regioselective C–H Alkenylation of <i>N,N</i>-Dialkylanilines with Ynamides
Xiao-Di Nie, Zhuo‐Ya Mao, Jia‐Ming Guo, Yuying Zhang, Bang‐Guo Wei, Guo‐Qiang Lin
Abstract
Regioselective C–H alkenylation of N,N-dialkylanilines with ynamides was developed using AgNTf2 as a catalyst. This approach represents a facile hydroarylation of ynamides, allowing for the introduction of an alkenyl group exclusively at the para position of aniline derivatives. As a result, a series of 4-alkenyl N,N-dialkylanilines were synthesized with excellent regioselectivities.
Topics & Concepts
RegioselectivityChemistryAnilineCatalysisMedicinal chemistryStereochemistryOrganic chemistryCatalytic C–H Functionalization MethodsCatalytic Alkyne ReactionsCyclopropane Reaction Mechanisms