Bladder infection with uropathogenic <i>Escherichia coli</i> increases the excitability of afferent neurons
Nicolás Montalbetti, Marianela G. Dalghi, Sheldon Bastacky, Dennis R. Clayton, Wily G. Ruiz, Gerard Apodaca, Marcelo D. Carattino
Abstract
(UPEC) promotes sensitization of bladder afferent sensory neurons with tetrodotoxin-resistant and tetrodotoxin-sensitive action potentials. Lipopolysaccharide and other virulence factors produced by UPEC contribute to the sensitization of bladder afferents in UTI. In conclusion, sensitized afferents contribute to the voiding symptoms and pelvic pain present in mice bladder inoculated with UPEC.
Topics & Concepts
SensitizationTetrodotoxinStimulationUrinary bladderPopulationSensory systemMedicineImmunologyInternal medicineBiologyNeuroscienceEnvironmental healthUrinary Bladder and Prostate ResearchUrinary Tract Infections ManagementClostridium difficile and Clostridium perfringens research