Effective Therapy Targeting Cytochrome <i>bc</i> <sub>1</sub> Prevents <i>Babesia</i> Erythrocytic Development and Protects from Lethal Infection
Joy E. Chiu, Isaline Renard, Anasuya Pal, Pallavi Singh, Pratap Vydyam, Jose Thekkiniath, Madelyn Kumar, Shalev Gihaz, Sovitj Pou, Rolf W. Winter, Rozalia A. Dodean, Lisa Frueh, Aaron Nilsen, Michael K. Riscoe, J. Stone Doggett, Choukri Ben Mamoun
Abstract
An effective strategy to control blood-borne diseases and prevent outbreak recrudescence involves targeting conserved metabolic processes that are essential for pathogen viability. One such target for Plasmodium and Babesia , the infectious agents of malaria and babesiosis, respectively, is the mitochondrial cytochrome bc 1 protein complex, which can be inhibited by endochin-like quinolones (ELQ) and atovaquone.
Topics & Concepts
AtovaquoneBabesiaBabesiosisBiologyVirologyMalariaPathogenOutbreakPlasmodium falciparumCytochrome bMicrobiologyImmunologyGeneGeneticsMitochondrial DNAMalaria Research and ControlMosquito-borne diseases and controlVector-borne infectious diseases