Opposite Effects of Apoptotic and Necroptotic Cellular Pathways on Rotavirus Replication
Mahmoud Soliman, Ja-Young Seo, Yeong‐Bin Baek, Jun‐Gyu Park, Mun-Il Kang, Kyoung‐Oh Cho, Sang‐Ik Park
Abstract
Viral infection usually culminates in cell death through apoptosis, necroptosis, and, rarely, pyroptosis. Necroptosis is a form of programmed necrosis that is mediated by signaling complexes of the receptor-interacting protein kinase 1 (RIPK1), RIPK3, and mixed-lineage kinase domain-like protein (MLKL).
Topics & Concepts
NecroptosisBiologyApoptosisProgrammed cell deathCell biologyRIPK1TransfectionSignal transductionKinaseCell cultureBiochemistryGeneticsViral gastroenteritis research and epidemiologyViral Infections and Outbreaks ResearchAnimal Virus Infections Studies