Metal transporter SLC39A14/ZIP14 modulates regulation between the gut microbiome and host metabolism
Samuel Blake Mitchell, Trista L. Thorn, Min-Ting Lee, Yongeun Kim, Janine M. C. Comrie, Zi Shang Bai, Elizabeth L. Johnson, Tolunay Beker Aydemir
2023American Journal of Physiology-Gastrointestinal and Liver Physiology18 citationsDOIOpen Access PDF
Abstract
Metal dyshomeostasis, intestinal permeability, and gut dysbiosis are emerging signatures of chronic disorders, including inflammatory bowel diseases, type-2 diabetes, and obesity. Studies in reciprocal regulations between host intestinal metal transporters genes and gut microbiome are scarce. Our research revealed a potential predisease microbial susceptibility state dependent on the host metal transporter gene, Slc39a14/Zip14, that contributes to intestinal permeability providing new insight into understanding host metal transporter gene-microbiome interactions in developing chronic disease.
Topics & Concepts
MicrobiomeTransporterDysbiosisHost (biology)BiologyIntestinal permeabilityGeneGut microbiomeBioinformaticsGeneticsImmunologyGut microbiota and healthChild Nutrition and Water AccessTrace Elements in Health