Bioinspired liquid gating membrane-based catheter with anticoagulation and positionally drug release properties
Chunyan Wang, Shuli Wang, Hong Pan, Lingli Min, Huili Zheng, Huang Zhu, Gang Liu, Weizhong Yang, Xinyu Chen, Xu Hou
Abstract
Catheters are indispensable medical devices that are extensively used in daily medical treatment. However, existing catheter materials continue to encounter many problems, such as thrombosis, single functionality, and inadaptability to environmental changes. Inspired by blood vessels, we develop a self-adaptive liquid gating membrane-based catheter with anticoagulation and positionally drug release properties. Our multifunctional liquid gating membrane-based catheter significantly attenuates blood clot formation and can be used as a general catheter design strategy to offer various drugs positionally releasing applications to comprehensively enhance the safety, functionality, and performance of medical catheters' materials.