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An engineered ScCas9 with broad PAM range and high specificity and activity

Pranam Chatterjee, Noah Jakimo, Jooyoung Lee, Nadia Amrani, Tomás Rodríguez, Sabrina Koseki, Emma Tysinger, Rui Qing, Shilei Hao, Erik J. Sontheimer, Joseph M. Jacobson

2020Nature Biotechnology137 citationsDOI

Topics & Concepts

CRISPRGenome editingCas9Computational biologyBiologyDNAMutantCleavage (geology)GeneticsGenePaleontologyFracture (geology)CRISPR and Genetic EngineeringMosquito-borne diseases and controlRNA and protein synthesis mechanisms
An engineered ScCas9 with broad PAM range and high specificity and activity | Litcius