Chitosan-Based Hydrogel Beads: Developments, Applications, and Challenges
Ziao Li, Ruoran Qin, Jiayi Xue, Congyu Lin, Longwei Jiang
Abstract
Currently, as research on hydrogel beads intensifies, the application scope of chitosan-based hydrogel beads is increasingly expanding. Owing to their unique three-dimensional network structure, chitosan-based hydrogel beads are frequently utilized for encapsulating bioactive substances and adsorbing impurities. The primary material used in the preparation of chitosan-based hydrogel beads is chitosan, which is uniquely a natural polysaccharide possessing a positive charge. Derived from a diverse array of sources, chitosan is non-toxic, exhibits excellent biocompatibility, and possesses certain antibacterial properties. Because of these remarkable attributes, it has found widespread application in tissue engineering, the formulation of drug carriers, and the adsorption of heavy metals and dyes in wastewater. The preparation method for chitosan-based hydrogel beads largely mirrors that of other hydrogel beads. According to existing research, numerous methods exist for crafting hydrogel beads with diverse properties. This paper reviews the preparation methods of chitosan-based hydrogel beads, encompassing both physical and chemical crosslinking techniques. The physical crosslinking method leverages electrostatic interactions between materials to form hydrogel beads, whereas the chemical crosslinking method involves the use of chemical crosslinking agents to facilitate the formation of hydrogel beads through material-based chemical reactions. Given that chitosan carries a positive charge and other polysaccharide materials possess a negative charge, the combination of these materials can yield hydrogel beads with a dense structure, effectively encapsulating bioactive substances. This dense internal structure offers superior protection for the encapsulated bioactive substances. Chitosan-based hydrogel beads typically feature large pore sizes, providing numerous adsorption sites, which makes them well suited for wastewater treatment. Additionally, this paper examines the recent applications of chitosan-based hydrogel beads in food preservation, medicine, and environmental protection. Starting with the materials and methods for preparing chitosan-based hydrogel beads, this paper delves into their applications in food preservation, biomedicine, and environmental protection, offering insights for future developments and applications of chitosan-based hydrogel beads and fostering further innovation and advancement in this field.