Combined phototherapy with metabolic reprogramming-targeted albumin nanoparticles for treating breast cancer
Xuan Thien Le, Junyeong Lee, Nguyen Thi Nguyen, Woo Tak Lee, Eun Seong Lee, Kyung Taek Oh, Han‐Gon Choi, Beom Soo Shin, Yu Seok Youn
Abstract
, which was 21 times smaller than that of the untreated group and was much lower than those of other single treatments after 21 days. Additionally, almost no systemic undesired toxicity was detected during the observation period. We believe that the concept of LCIR as presented here offers a potential platform to overcome the resistance to conventional therapies by the incorporation with the energy metabolism inhibition approach.
Topics & Concepts
Triple-negative breast cancerCancer cellReprogrammingChemistryCancer researchOxidative phosphorylationCancerBreast cancerIn vivoMitochondrionGlycolysisPhotodynamic therapyPhotothermal therapyHypoxia (environmental)PharmacologyMetabolismMedicineBiochemistryBiologyInternal medicineCellOxygenNanotechnologyMaterials scienceOrganic chemistryBiotechnologyCancer, Hypoxia, and MetabolismNanoplatforms for cancer theranosticsPhotodynamic Therapy Research Studies