Three weeks of interrupting sitting lowers fasting glucose and glycemic variability, but not glucose tolerance, in free-living women and men with obesity
Jonathon A. B. Smith, Mladen Savikj, Parneet Sethi, Simon Platt, Brendan M. Gabriel, John A. Hawley, David W. Dunstan, Anna Krook, Juleen R. Zierath, Erik Näslund
Abstract
Under free-living conditions, breaking sitting modestly increased activity behavior. Breaking sitting was insufficient to modulate glucose tolerance or the skeletal muscle lipidome. Activity breaks reduced fasting blood glucose levels and daily glucose variation compared with baseline, with a tendency to also decrease fasting LDLc. This intervention may represent the minimal dose for breaking sedentary behavior, with larger volumes of activity possibly required to promote greater health benefits.
Topics & Concepts
GlycemicInternal medicineLipidomeEndocrinologySittingMedicineObesityFasting glucoseDiabetes mellitusInsulin resistanceLipid metabolismPathologyPhysical Activity and HealthObesity, Physical Activity, DietCardiovascular and exercise physiology