NDR1/FBXO11 promotes phosphorylation-mediated ubiquitination of β-catenin to suppress metastasis in prostate cancer
Zuodong Xuan, Chen Chen, Huimin Sun, Kunao Yang, Jinxin Li, Meilin Fu, Yang Bai, Zeyuan Zheng, Yue Zhao, Chunlan Xu, Bin Liu, Tian Li, Chen Shao
Abstract
The NDR1/FBXO11 axis outlines a non-canonical β-catenin degradation pathway crucial in regulating EMT and prostate cancer cell metastasis. NDR1 activation, particularly with aNDR1, could offer a promising therapeutic avenue against prostate cancer metastasis.
Topics & Concepts
PhosphorylationProstate cancerMetastasisCancer researchCancerUbiquitinCateninMedicineOncologyInternal medicineBiologyWnt signaling pathwaySignal transductionCell biologyBiochemistryGeneMechanisms of cancer metastasisProtein Hydrolysis and Bioactive Peptides