Three-Component Ruthenium-Catalyzed <i>meta</i>-C–H Alkylation of Phenol Derivatives
Yu‐Yong Luan, Xue‐Ya Gou, Wei‐Yu Shi, Hongchao Liu, Xi Chen, Yong‐Min Liang
Abstract
Herein, we realized the multicomponent reactions of phenol derivatives via a six-membered cycloruthenated intermediate for the first time. This strategy exhibited good substrate suitability and functional group tolerance with various phenol derivatives and provided a potential synthetic drug approach. Mechanistic studies showed that a radical might be involved in this process. In addition, the meta alkylated phenol was obtained by further removal of the directing group.
Topics & Concepts
PhenolChemistryAlkylationRutheniumCatalysisSubstrate (aquarium)Functional groupCombinatorial chemistryOrganic chemistryPolymerGeologyOceanographyCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsAsymmetric Hydrogenation and Catalysis