Nuclear receptor RORγ inverse agonists/antagonists display tissue- and gene-context selectivity through distinct activities in altering chromatin accessibility and master regulator SREBP2 occupancy
Hongye Zou, Yatian Yang, Zhenrui Shi, Xuesong Wu, Ruiwu Liu, Ai‐Ming Yu, Hong-Wu Chen
Topics & Concepts
ChromatinNuclear receptorOrphan receptorBiologyRAR-related orphan receptor gammaCoactivatorCell biologyRegulatorChromatin immunoprecipitationCancer researchTranscription factorGeneGene expressionPromoterBiochemistryCytokine Signaling Pathways and InteractionsImmune Cell Function and InteractionChemokine receptors and signaling