Novel sulfonamide-tethered Schiff bases as anti-proliferative agents with VEGFR-2 inhibitory activity: Synthesis, biological assessment, and molecular dynamic simulations
Moataz A. Shaldam, Maha‐Hamadien Abdulla, Andrea Angeli, Salma M. Hefny, Eman M. El‐labbad, Abdullah Bin Obeed, Noura Alhassan, Claudiu T. Supuran, Wagdy M. Eldehna, Haytham O. Tawfik
Topics & Concepts
ChemistryCarbonic anhydraseApoptosisCancer cellCarbonic anhydrase IIIC50EnzymeIn silicoSulfonamideStereochemistryGene isoformBiochemistryPharmacologyCancerIn vitroMedicineGeneInternal medicineEnzyme function and inhibitionSynthesis and biological activitySynthesis and Catalytic Reactions