Synthesis, Intramolecular Cyclization, and Antinociceptive Activity of Substituted 2-[2-(4-Nitrobenzoyl)hydrazinylidene]-4-oxobut-2-enoic Acids
E. I. Denisova, D. V. Lipin, K. Yu. Parkhoma, I. О. Devyatkin, D. A. Shipilovskikh, С. В. Чащина, Р. Р. Махмудов, Н. М. Игидов, Sergei A. Shipilovskikh
Abstract
Abstract New substituted 2-[2-(4-nitrobenzoyl)hydrazinylidene]-4-oxobut-2-enoic acids have been synthesized by condensation of 4-nitrobenzohydrazide with 4-aryl-2,4-dioxobutanoic acids, and their intramolecular cyclization in the presence of propionic anhydride afforded the corresponding substituted 3-[2-(4-nitrobenzoyl)hydrazinylidene]furan-2(3H)-ones. The synthesized compounds were evaluated for their antinociceptive activity.
Topics & Concepts
ChemistryIntramolecular forceArylFuranCondensationOrganic chemistryMedicinal chemistryAlkylPhysicsThermodynamicsChemical synthesis and pharmacological studiesSynthesis of heterocyclic compoundsSynthesis and Biological Evaluation