Improving the physicochemical and pharmacokinetic properties of olaparib through cocrystallization strategy
Xia-Lin Dai, Bowen Pang, Wenting Lv, Jian-Feng Zhen, Lu Gao, Caiwen Li, Jing Xiong, Tong‐Bu Lu, Jia‐Mei Chen
Topics & Concepts
CocrystalFumaric acidPharmacokineticsChemistryCmaxSolubilityMaleic acidOlaparibBioavailabilityAbsorption (acoustics)Oxalic acidBiopharmaceutics Classification SystemFourier transform infrared spectroscopyNuclear chemistryCombinatorial chemistryMaterials scienceOrganic chemistryHydrogen bondChemical engineeringPolymerMoleculePharmacologyMedicineEngineeringPoly ADP ribose polymeraseComposite materialCopolymerEnzymePolymeraseCrystallography and molecular interactionsProtein Structure and DynamicsMass Spectrometry Techniques and Applications