Systemic IL-15, IFN-γ, and IP-10/CXCL10 signature associated with effective immune response to SARS-CoV-2 in BNT162b2 mRNA vaccine recipients
Cristina Bergamaschi, Evangelos Terpos, Margherita Rosati, Matthew Angel, Jenifer Bear, Dimitris Stellas, Sevasti Karaliota, Filia Apostolakou, Tina Bagratuni, Dimitris Patseas, Sentiljana Gumeni, Ioannis P. Trougakos, Meletios Α. Dimopoulos, Barbara K. Felber, George N. Pavlakis
Abstract
vaccination. In previously COVID-19-infected individuals, a single vaccination results in both strong cytokine induction and antibody titers similar to the ones observed upon booster vaccination in antigen-naive individuals, a result with potential implication for future public health recommendations.
Topics & Concepts
VaccinationImmunologyImmunogenicityImmune systemCXCL10AdjuvantMedicineChemokineImmunityAntibodyCytokineVirologyBiologySARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections StudiesImmunotherapy and Immune Responses