Synthesis of Deuterated Compounds by Flow Chemistry
Shintaro Kamio, Kazuhiro Okamoto, Takehiro Yamagishi, Aiichiro Nagaki
Abstract
Development of the efficient and practical method for the synthesis of deuterated compounds which occupies the broadest area among stable isotopes is one of the most essential issues toward the industrial advance and building a sustainable society. This review describes recent advances in deuteration reactions, where the continuous flow chemistry plays pivotal roles for the successful installation of deuterium atom into diverse organic frameworks, opening new fields of isotope-based synthetic chemistry.
Topics & Concepts
DeuteriumChemistryFlow chemistryContinuous flowNanotechnologyCombinatorial chemistryComputational chemistryOrganic chemistryBiochemical engineeringMaterials scienceCatalysisNuclear physicsEngineeringPhysicsChemical Reactions and IsotopesInnovative Microfluidic and Catalytic Techniques InnovationAsymmetric Hydrogenation and Catalysis