Prevalence and Characterization of the Cefazolin Inoculum Effect in North American Methicillin-Susceptible Staphylococcus aureus Isolates
Tanis C. Dingle, Dulini Gamage, Sara I Gómez-Villegas, Blake Hanson, Jinnethe Reyes, April N. Abbott, Carey‐Ann D. Burnham, Jennifer Dien Bard, Stephanie A. Fritz, William R. Miller, Lars F. Westblade, Barbara Zimmer, César A. Arias, Susan M. Butler‐Wu
Abstract
< 0.0001). The most common BlaZ β-lactamase types found in the CzIE-positive strains were type C (53.7%) and type A (44.4%). ST8 and ST30 were the most common sequence types among CzIE-positive isolates and correlated with BlaZ type C and A, respectively. The CzIE was present in up to a quarter of clinical MSSA isolates from North American clinical laboratories. Further studies to determine the impact of the presence of the CzIE on clinical outcomes are needed.
Topics & Concepts
CefazolinBroth microdilutionMicrobiologyStaphylococcus aureusBiologyMeticillinVeterinary medicineMicrococcaceaeBacteriaAntibacterial agentAntibioticsMedicineMinimum inhibitory concentrationGeneticsAntimicrobial Resistance in StaphylococcusAntibiotic Resistance in BacteriaBacterial Identification and Susceptibility Testing