Immunosuppressive and Adipogenesis Inhibitory Sesterterpenoids with a Macrocyclic Ether System from <i>Eurysolen gracilis</i>
Lin-Lin Teng, Rong‐Fang Mu, Yanchun Liu, Chao‐Jiang Xiao, Desen Li, Jianxiong Gao, Kai Guo, Xiao‐Nian Li, Yan Liu, Fang Zeng, Sheng‐Hong Li
Abstract
Eurysoloids A (1) and B (2), two novel diastereomeric sesterterpenoids possessing a pentacyclic 5/6/5/10/5 framework with an unusual macrocyclic ether system, were isolated from Eurysolen gracilis Prain. Their structures were unambiguously determined by spectroscopic, single-crystal X-ray diffraction and DP4+ analyses. A plausible biosynthetic pathway for compounds 1 and 2 was proposed. Both compounds exhibited immunosuppressive activity via inhibiting the production of cytokine IFN-γ of T cells, and compound 2 inhibited adipogenesis in 3T3-L1 adipocytes.
Topics & Concepts
ChemistryAdipogenesisDiastereomerStereochemistryEtherInhibitory postsynaptic potentialBiochemistryIn vitroOrganic chemistryBiologyNeurosciencePlant biochemistry and biosynthesisNatural product bioactivities and synthesisPhytochemical compounds biological activities