Design, synthesis, and pharmacological evaluation of novel benzothiazole derivatives targeting LCK in acute lymphoblastic leukemia
Yanmei Chen, Kai Zhang, Jiacheng Tan, Zhichao Fan, Yuqi Fu, Xiang Li, Bo Liu, Guan Wang
Topics & Concepts
ChemistryTyrosine kinaseBenzothiazoleSrc family kinaseLeukemiaCancer researchKinaseApoptosisCell growthProto-oncogene tyrosine-protein kinase SrcSignal transductionCell biologyJurkat cellsCell cycleBiochemistryT cellBiologyImmune systemImmunologyAcute Lymphoblastic Leukemia researchChronic Myeloid Leukemia TreatmentsQuinazolinone synthesis and applications