Synthesis, antimicrobial properties, and theoretical analysis of benzimidazole-2-ylidene silver(I) complexes
Serpil Demir Düşünceli, Dilek Ayaz, Elvan Üstün, Selamı Günal, Namık Özdemir, Muharrem Di̇nçer, İsmaıl Özdemır
Abstract
A series of symmetrical and nonsymmetrical N,N-disubstituted benzimidazolium salts were synthesized as N-heterocyclic carbene precursors. These salts were treated with Ag2O to afford their corresponding mononuclear Ag(I)-NHC complexes. These compounds were characterized by spectroscopy techniques and analyzed by DFT/TDDFT and docking methods. Also, the structures of 2a and 2e were determined by single-crystal X-ray crystallography. These new Ag–NHC complexes were screened for their antibacterial activities against Gram-positive, Gram-negative bacteria, fungi, and nosocomial agents.
Topics & Concepts
ChemistryBenzimidazoleAntimicrobialCarbeneCrystal structureCombinatorial chemistryTime-dependent density functional theoryStereochemistryMedicinal chemistryOrganic chemistryMoleculeCatalysisN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCatalytic Cross-Coupling ReactionsSynthetic Organic Chemistry Methods