Visible-Light Induced Organophotocatalysis for the Synthesis of Difluoroethylated Benzoxazines
Xiang Chen, Wen‐Tao Ouyang, Xiao Li, Wei‐Min He
Abstract
Benzoxazines are important motif in pharmaceuticals and functional molecules.A visible-light induced photocatalytic strategy for the synthesis of difluoroethyl benzoxazines with organo-photocatalyst was developed.In the present protocol, a series of olefinic amides can be transferred to difluoroethylated benzoxazines via oxydifluoromethylation with CF2HSO2Na as difluoromethylating reagent, which is easily operated and good functional group tolerant.
Topics & Concepts
ChemistryCombinatorial chemistryFluorine in Organic ChemistryRadical Photochemical ReactionsSulfur-Based Synthesis Techniques