Transferable Resistance Gene <i>optrA</i> in Enterococcus faecalis from Swine in Brazil
Lara Mendes de Almeida, François Lebreton, Anthony O. Gaca, Paulo J. M. Bispo, José T. Saavedra, Rodrigo N. Calumby, Luciano Aparecido Meireles Grillo, Ticiano Gomes do Nascimento, Pedro H. Filsner, Andréa Micke Moreno, Michael S. Gilmore
Abstract
OptrA is an ATP-binding cassette (ABC)-F protein that confers resistance to oxazolidinones and phenicols and can be either plasmid-encoded or chromosomally encoded. Here, we isolated 13 Enterococcus faecalis strains possessing a linezolid MIC of ≥4 mg/liter from nursery pigs in swine herds located across Brazil. Genome sequence comparison showed that these strains possess optrA in different genetic contexts occurring in 5 different E. faecalis sequence type backgrounds.
Topics & Concepts
Enterococcus faecalisBiologyEnterococcusPlasmidLinezolidMicrobiologyGeneWhole genome sequencingGeneticsStreptococcaceaeMicrobial geneticsGenomeBacteriaEscherichia coliVancomycinStaphylococcus aureusAntimicrobial Resistance in StaphylococcusMycobacterium research and diagnosisMicrobial infections and disease research