Blood‐circulating EV‐miRNAs, serum TARC, and quantitative FDG‐PET features in classical Hodgkin lymphoma
Esther E.E. Drees, Julia Driessen, Gerben J.C. Zwezerijnen, Sandra A.W.M. Verkuijlen, Jakoba J. Eertink, Monique A.J. van Eijndhoven, Nils J. Groenewegen, Andrea Vallés‐Martí, Daphne de Jong, Ronald Boellaard, Henrica C. W. de Vet, D. Michiel Pegtel, Josée M. Zijlstra
Abstract
Abstract Blood‐based biomarkers are gaining interest for response evaluation in classical Hodgkin lymphoma (cHL). However, it is unknown how blood‐based biomarkers relate to quantitative 18 F‐FDG‐PET features. We correlated extracellular vesicle‐associated miRNAs (EV‐miRNA), serum TARC, and complete blood count (CBC) with PET features (e.g., metabolic tumor volume [MTV], dissemination and intensity features) in 30 cHL patients at baseline. EV‐miR127‐3p, EV‐miR24‐3p, sTARC, and several CBC parameters showed weak to strong correlations with MTV and dissemination features, but not with intensity features. Two other EV‐miRNAs only showed weak correlations with PET features. Therefore, blood‐based biomarkers may be complementary to PET features, which warrants further exploration of combining these biomarkers in prognostic models.