Microtubule Acetylation-Specific Inhibitors Induce Cell Death and Mitotic Arrest via JNK/AP-1 Activation in Triple-Negative Breast Cancer Cells
Suyeon Ahn, Ahreum Kwon, Youngsoo Oh, Sangmyung Rhee, Woo Keun Song
Abstract
, validating the significance of microtubule acetylation/JNK/AP-1 axis activation in the anti-cancer activity of GM compounds. Moreover, GM compounds significantly attenuated tumor growth, metastasis, and cancer-related death in mice, demonstrating strong potential as therapeutic agents for TNBC.
Topics & Concepts
Triple-negative breast cancerAcetylationCancer researchProgrammed cell deathc-junKinaseMitosisMicrotubuleCancer cellBiologyTranscription factorCell biologyChemistryCancerBreast cancerApoptosisBiochemistryGeneticsGeneUbiquitin and proteasome pathwaysCancer Cells and MetastasisCancer-related Molecular Pathways