The Arginine Biosynthesis Pathway of Candida albicans Regulates Its Cross-Kingdom Interaction with Actinomyces viscosus to Promote Root Caries
Kaixin Xiong, Hualing Zhu, Yanyao Li, Mengzhen Ji, Yujia Yan, Xuan Chen, Yaqi Chi, Xueqin Yang, Ling Deng, Xuedong Zhou, Ling Zou, Biao Ren
Abstract
Root caries is a critical problem that threatens the oral health of the elderly population. Our results identified the essential roles of the C. albicans arginine biosynthesis pathway in its cross-kingdom interactions with A. viscosus in root caries for the first time and indicated that targeting this pathway was a practical way to treat root caries caused by multiple species.
Topics & Concepts
Candida albicansBiofilmBiosynthesisCorpus albicansArginineMicrobiologyRoot cariesActinomycesMutantChemistryBiologyBacteriaGeneBiochemistryMedicineDentistryAmino acidGeneticsAntifungal resistance and susceptibilityPeptidase Inhibition and AnalysisOral microbiology and periodontitis research