Antiproliferative Potential of Gloriosine: A Lead for Anticancer Drug Development
Bharat Goel, Biswajit Dey, Essha Chatterjee, Nancy Tripathi, Nivedita Bhardwaj, Sanjay Kumar, Santosh Kumar Guru, Shreyans K. Jain
Abstract
) was investigated for its apoptosis-inducing ability and found to form apoptotic bodies. It also inhibited A549 cell migration in the wound healing assay. Finally, molecular docking studies were performed to explore the possible binding modes of gloriosine with the colchicine-binding site of tubulin protein. Our findings suggested that gloriosine might be a potential lead for anticancer drug discovery.
Topics & Concepts
ColchicineApoptosisNatural productChemistryDocking (animal)Cell cultureCancer cellTubulinIC50DrugPharmacologyBiochemistryIn vitroBiologyCancerCell biologyMicrotubuleMedicineGeneticsNursingSynthesis and biological activityBioactive Compounds and Antitumor AgentsNatural product bioactivities and synthesis