Hypoxia in Cell Reprogramming and the Epigenetic Regulations
Nariaki Nakamura, Xiaobing Shi, Radbod Darabi, Yong Li
Abstract
Cellular reprogramming is a fundamental topic in the research of stem cells and molecular biology. It is widely investigated and its understanding is crucial for learning about different aspects of development such as cell proliferation, determination of cell fate and stem cell renewal. Other factors involved during development include hypoxia and epigenetics, which play major roles in the development of tissues and organs. This review will discuss the involvement of hypoxia and epigenetics in the regulation of cellular reprogramming and how interplay between each factor can contribute to different cellular functions as well as tissue regeneration.
Topics & Concepts
ReprogrammingEpigeneticsBiologyCell fate determinationCell biologyStem cellEpigenesisHypoxia (environmental)Cellular differentiationRegeneration (biology)CellNeuroscienceDNA methylationTranscription factorGeneticsChemistryGene expressionGeneOxygenOrganic chemistryPluripotent Stem Cells ResearchEpigenetics and DNA MethylationPancreatic function and diabetes