Lecanemab reduces brain amyloid-β and delays cognitive worsening
David S. Knopman
Abstract
Lecanemab cleared amyloid-β in two-thirds and reduced the rate of cognitive and functional worsening in people with mild cognitive impairment and mild dementia due to Alzheimer disease in an 18-month double-blinded randomized placebo-controlled trial reported by van Dyck et al.
Topics & Concepts
ClearanceDementiaCognitionPlaceboCognitive impairmentAmyloid (mycology)MedicineRandomized controlled trialAlzheimer's diseaseCognitive declineDiseaseInternal medicinePsychologyNeurosciencePsychiatryPathologyUrologyAlternative medicineAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsDementia and Cognitive Impairment Research