Modulation of hypoxia and redox in the solid tumor microenvironment with a catalytic nanoplatform to enhance combinational chemodynamic/sonodynamic therapy
Yeping Liu, Likai Wang, Fengyuan Wei, Ya Tian, Juan Mou, Shiping Yang, Huixia Wu
Abstract
/OCN-PpIX@BSA nanocomposites exhibit minimal toxicity to normal tissues at therapeutic doses. These positive findings provide a new strategy for the convenient construction of TME-regulating smart theranostic nanoagents to improve the therapeutic outcomes towards malignant tumors effectively.
Topics & Concepts
Sonodynamic therapyChemistryHypoxia (environmental)RedoxCatalysisTumor microenvironmentCancer researchBiophysicsReactive oxygen speciesOxygenBiochemistryTumor cellsMedicineBiologyInorganic chemistryOrganic chemistryNanoplatforms for cancer theranosticsLuminescence and Fluorescent MaterialsNanoparticle-Based Drug Delivery